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KMID : 0613820080180101415
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Journal of Life Science
2008 Volume.18 No. 10 p.1415 ~ p.1419
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Inhibitory Effects of Methanol Extracts from Korean Orysa sartiva and Coix lachryma-jobi var. ma-yuen on Mutagenicity and Growth of Human Cancer Cells
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Lim Sun-Young
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Abstract
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This study was carried out to determine the inhibitory effects of methanol extracts from Korean Orysa sartiva and Coix lachryma-jobi var. ma-yuen on mutagenicity using Ames test and growth of AGS human gastric adenocarcinoma and HT-29 human colon cancer cells. Both treatments of methanol extracts (5 ㎎/assay) from Orysa sartiva and Coix lachryma-jobi var. ma-yuen to Ames test system inhibited aflatoxin B₁ (AFB₁) induced mutagenicity by 76%. In case of N-methyl-N’-nitro-N-nitrosoguamidine (MNNG) induced mutagenicity, the methanol extracts (5 ㎎/assay) from Orysa sartiva and Coix lachryma-jobi var. ma-yuen showed 79% and 69% inhibitory rate, respectively and the inhibitory effect was a little stronger in Orysa sartiva Inhibitory effects of methanol extracts from Orysa sartiva. and Coix lachryma-jobi var. ma-yuen on the growth of AGS and HT-29 human cancer cells were increased as dose dependent patterns and the inhibitory effects on AGS and HT-29 cells were similar. The above results indicate that the consumption of these cereals, which contain many nutrients with good quality, may be recommended as potent functional foods for improving health.
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KEYWORD
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Orysa sartiva, Coix lachryma-jobi var, ma-yuen, antimugenicity, human cancer cell, Ames test
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